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Review Article
Autoimmunity
Joong Gon Kim
Clin Exp Pediatr. 2007;50(12):1165-1172.   Published online December 15, 2007
Self/non-self discrimination and unresponsiveness to self is the fundamental properties of the immune system. Self-tolerance is a state in which the individual is incapable of developing an immune response to an individual's own antigens and it underlies the ability to remain tolerant of individual's own tissue components. Several mechanisms have been postulated to explain the tolerant state. They can be...
Original Article
A clinical analysis of juvenile dermatomyositis; focus on clinical manifestations at diagnosis
So Young Lee, Ji Seok Bang, Hee Seok Kim, Joong Gon Kim
Clin Exp Pediatr. 2007;50(11):1116-1124.   Published online November 15, 2007
Purpose : Juvenile dermatomyositis (JDM) is the most common of the idiopathic inflammatory myopathies in children. The purpose of this study is to observe demographic, initial presentations, duration of time between disease onset and diagnosis, clinical manifestations and laboratory findings at diagnosis of patients with JDM. Methods : Forty seven patients identified at Seoul National University Children's Hospital from January 1986...
Association of Diagnostic Criteria and Autoantibodies with Juvenile Dermatomyositis in Newly Diagnosed Children
Kyung Sue Shin, Joong Gon Kim
Clin Exp Pediatr. 2003;46(9):898-902.   Published online September 15, 2003
Purpose : To determine the clinical association of diagnostic criteria and the prevalence of autoantibodies in newly diagnosed children with juvenile dermatomyositis(JDM). Methods : Thirty-two children with JDM were identified at Seoul National University Children's Hospital from March 1985 to March 1999 by retrospective review. The diagnosis of JDM was based on the criteria proposed by Bohan and Peter. We investigated...
Clinical Lecture
Immunotherapy for Rheumatoid Arthritis
Joong Gon Kim
Clin Exp Pediatr. 2001;44(11):1215-1221.   Published online November 15, 2001
Original Article
Clinical Significance of CD7 Expression in Acute Myelocytic Leukemia
Gye Jin Yoon, Pill Sang Jang, Young Choi, Jun A Lee, Hyo Jung Han, Hyoung Soo Choi, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1999;42(3):374-382.   Published online March 15, 1999
Purpose : It has been shown that a considerable number of acute myeloid leukemia(AML) patients had both myeloid and lymphoid antigens. CD7 is a lymphoid antigen, often expressed in AML cells. We investigated 40 AML patients to clarify the relationship between the cellular characteristics and clinical features. Methods : We reviewed 8 CD7 positive(CD7＋) AML patients and 32 CD7 negative(CD7－)...
Immunomodulation Therapy in Aplastic Anemia : Relapse Rate, Complications and Long-term Survival During Follow-up for More than 1 Year
Jun Ah Lee, Hyoung Jin Kang, Hyo Jeong Han, Hyoung Soo Choi, Eun Sun Yoo, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(6):775-784.   Published online June 15, 1998
Purpose : We evaluated the response to immunomodulation therapy, long-term survival and relapse rate of aplastic anemia during follow-up for more than 1 year. Methods : Twenty-eight children, with moderate to severe aplastic anemia were followed for more than one year and 7 children expired after therapy, were analyzed. Antilymphocyte globulin(ALG) or antithymocyte globulin(ATG) by itself was given to 27 patients, and cyclosporine A(CsA)...
Basophil Histamine Releasability in Asthmatic Children
Seon Mi Jin, Jin Hwa Jung, Yong Han Sun, Myung Hyun Lee, Joong Gon Kim, Young Yull Koh
Clin Exp Pediatr. 1998;41(1):99-109.   Published online January 15, 1998
Purpose : The release of histamine from human basophils is controlled by an intrinsic, as yet unidentified, cellular property termed “releasability.” We carried out this study to ascertain whether there was any difference in the releasability of basophils from asthmatic children compared to those from normal children. We intended also to clarify the correlation between the releasability and the atopic status of asthma. Methods :...
Case Report
A Case Report of Autoimmune Hepatitis Associated with Choledochal Cyst and Pancreatitis
Kyung Ran Park, Sun Young Lee, Soon Young Kim, Hyoung Shim Chang, Nam Su Back, Chong Jai Kim, Joong Gon Kim, Jeong Kee Seo
Clin Exp Pediatr. 1996;39(8):1146-1150.   Published online August 15, 1996
Autoimmune hepatitis in children is a rare and severe inflammatory disease of unknown etiology, and progress to cirrohosis and liver failure, generally is responsive to immunosuppressive therapy. It is more prevalent in women than men, and characterized by the presence of circulating autoantibodies, a high serum globulin. Extrahepatic manifestations such as thyroiditis, ulcerative colitis, glomerulonephritis and autoimmune hemolytic anemia, are associated. We report, to our...
Isolated Splenic Infarction in a Girl with Systemic Lupus Erythematosus
Kyung Ran Park, Hee Eun Lee, Yun Ae Jeon, Il Soo Ha, Hae Il Cheong, Joong Gon Kim, Yong Choi
Clin Exp Pediatr. 1996;39(4):562-566.   Published online April 15, 1996
Splenic infarction is a rare disease and usually detected as a complication of SBE, atrial fibrillation, hemoglobinopathy, or myeloproliperative disorders. Although thrombotic event, such as deep vein, cerebral or renal thrombosis, is a frequent complication of SLE, there have been only a couple of cases documenting splenic infarction complicated in SLE. This is, to our knowledge, the first case report...
Original Article
The Effect of IFN-γ and PGE2 in the Production of TNF-α by Human PBMC Stimulated with LPS
Youn Soo Hahn, Joong Gon Kim
Clin Exp Pediatr. 1996;39(2):255-264.   Published online February 15, 1996
Purpose : The purpose of this study was to observe the effect of IFN-γ and PGE2 on TNF-α production by human peripheral mononuclear cells(PBMC) that were stimulated with LPS. Methods : PBMC were separated by Ficoll-Hypaque gradient centrifugation from human peripheral venous blood and were incubated for 72 hours with or without LPS, IFN-γ, PGE2, and indomethacin according to various conditions. TNF-α activity of...
Clinical Study on Chronic Granulomatous Disease (CGD) -Occurrence in Siblings-
Yong Hoon Jun, Sung Won Yang, Dong Wook Kim, Hoan Jong Lee, Joong Gon Kim
Clin Exp Pediatr. 1994;37(6):794-803.   Published online June 15, 1994
To analyse the age of onset, etiologic microorgnisms, clinical manifestations, managements and genetic variation of chronic granulomatous disease, the authors reviewed four patients who were diagnosed as CGD at Department of Pediatrics, Seoul National Univesity Children's Hospital. They were siblings in relationship-two of them were brothers, the others wete brother-sister. The results were as follows; 1) Initial manifestations developed within 1...
Case Report
Candida Esophagitis in Infancy-A Report of 3 Cases
Ho Sung Kim, Youn Woo Kim, Jae Geon Sim, Beom Soo Park, Hoan Jong Lee, Joong Gon Kim, Jeong Kee Seo, Je Geun Chi
Clin Exp Pediatr. 1994;37(2):269-275.   Published online February 15, 1994
We experienced 3 cases of Candida esophagitis in infancy which were diagnosed by esophageal endoscopy, First case, 10 month-old boy with combined immune deficiency had suffered from oral thrush and poor feeding for more than 4 months. Esophageal endoscopy revealed multiple whitish creamy patches on the friable erythematous and necrotic mucosa of the esophagus, He was firstly treated with amphotericin-B...
Medical Lecture Course
Differentiation Of B Cell
Joong Gon Kim
Clin Exp Pediatr. 1993;36(7):901-905.   Published online July 15, 1993
Original Article
Clinical Significance of Rheumatoid Factor in Juvenile Rheumatoid Arthritis
Ki Joong Kim, Bo Young Yun, Joong Gon Kim
Clin Exp Pediatr. 1992;35(5):639-645.   Published online May 15, 1992
Rheumatoid factor is a commonly used laboratory test by clinicians to assess the children with possible juvenile rheumatoid arthritis. To assess its diagnositc value and clinical significance we reviewed the case histories of the patients in whom latex agglutinating rheumatoid factor was tested during November 1988 to April 1991 at Seoul National University Children's Hospital. There were 61 patients with...
The Clinical Observation in Kawasaki Disease
Young Jin Jang, Joong Gon Kim, Yong Soo Yun
Clin Exp Pediatr. 1992;35(3):330-341.   Published online March 15, 1992
The one-hundred thirty five cases with Kawasaki disease who wre diagnosed and treated at the department of pediatrics, Seoul National University Children뭩 Hospital from September 1984 to December 1990, were investigated for clinical pattrns and laboratory correlations. The results were as follows; 1) Most patients (86%) were under 4 years of the age. 2) boys wee more prevalent than girls, as a ratio...
Immune response induced by live attenuated varicella vaccine(Biken@) in children with acute lymphoblastic leukemia.
Hyo Seop Ahn, Joong Gon Kim
Clin Exp Pediatr. 1991;34(9):1255-1260.   Published online September 30, 1991
To determine the safety and efficacy of varicella vaccine, we studied 10 healthy children and 12 children in remission from acute lymphoblastic leukemia. They were immunized with the Oka strain of live attenuated varicella vaccine (Biken®). All the healthy children and 6 children with leukemia received the vaccine of 1,000 plaque-forming units (PFU), and 6 leukemic children received the vaccine of 500 PFU. The...
A case of the lupus syndrome induced by hydralazine.
Beom Soo Park, Joong Gon Kim, Yong Soo Yun
Clin Exp Pediatr. 1991;34(5):736-739.   Published online May 31, 1991
A reversible syndrome resembling systemic lupus erythematosus is induced by hydralazine which has been used in treatment of hypertension or congestive heart failure. The incidence of the lupus syndrome induced by hydralazine was estimated at 6.8% in adults (Cameron, 1984) but there was few reports in children. A 9 year old girl had arthralgia, fever, splenomegaly, pleurisy and oral ulcer after 62 months of hydralazine...
A clinical study on histiocytosis X.
Sang Oh Na, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(11):1510-1519.   Published online November 30, 1989
We made a clinical study on 31 cases of histiocytosis X who had been admitted to the Dept, of Ped. of S.N.U.C.H. from Jan. 1981 to Dec. 1987. Among 31 cases, 28 patients received chemotherapy to include prednisolone, vinblastine, methotrex- ate and cyclophosphamide as induction therapy, and 6-mercaptopurine, methotrexate and cyclophos- phamide as maintenance therapy. The results obtained were as follows. 1) The sex incidence revealed male...
Case Report
A Case of Congestive Cardiomyopathy.
Ghee Young Jung, Joong Gon Kim, Keun Lee
Clin Exp Pediatr. 1983;26(7):726-730.   Published online July 31, 1983
We have experienced a case of congestive cardiomyopathy in a 4-year-old boy who had progressive cardiomegaly, congestive heart failure and weakness of right upper and lower extremities. On necropsy, the heart showed hypertrophy of cardiac muscle with focal granular degeneration. Clinical course of the case was reported with review of literature.
A Case of Chaotic Atrial Tachycardia.
Jung Hee Park, Eun Ai Lee, Joong Gon Kim, Keun Lee
Clin Exp Pediatr. 1983;26(2):180-182.   Published online February 28, 1983
A 1.5 month-old male with rapid and irregular pulse rate had an uncommon form of atrial tachycardia. The electrocardiogram was compatable with the diagnosis of chaotic atrial tachycardia or multifocal atrial tachycardia. The patient was treated with digoxin.
A Case of Morgagni Hernia Confirmed by Diagnostic Pneumoperitoneum.
Young Mi Hong, Hae Seung Kim, Joong Gon Kim, Keun Lee, Seung Yeul Yoo
Clin Exp Pediatr. 1982;25(12):1266-1269.   Published online December 31, 1982
A case of Morgagni hernia in 3day old newborn is reported with literature review. The patient developed tachypnea and respiratory difficulty on 3rd day of life and the diagnosis was made by diagnostic pneumoperitoneum.
Original Article
Estimation of Fetal Growth by Measurement of Birth Weight for Gestational Age in Newborn.
Ja Young Park, Joong Gon Kim, Keun Lee
Clin Exp Pediatr. 1982;25(7):649-655.   Published online July 31, 1982
Birth weight and gestational age are two important factors in assessing the neonatal mortality and morbidity. We collected the birth weights of 10,242 newborns who were born at Ewha Womans University Hospital from June, 1976 to June, 1981, including birth weight and gestational age. Mean birth weight with standard deviation for each gestational age and fetal growth curve are presented...
Case Report
Hyaline Membrane Disease (Five cases report including two autopsy cases).
Jun Hee Kang, Young Min Ahn, Joong Gon Kim, Chun Haeng Park, Jeong Kee Seo, Ok Ja Hwang, Chong Ku Yun, Yoon Seong Lee, Shin Eun Choi, Je G Chi
Clin Exp Pediatr. 1981;24(9):882-890.   Published online September 15, 1981
The hyaline membrane disease is not a common disease in Korea. Only a few reports of small scale are avaiable in the literature. We have experienced 5 cases of HMD during approximately 1 year period. The diagnosis was made either on characteristic clinical and roentgenological features or postmortem examination. The birth weights of these cases were in the range of...
A Case of Moyamoya Disease in Child.
Joong Gon Kim, Sang Il Lee, Baek Youn Choo, Kwang Chan Do, Chong Ku Yun
Clin Exp Pediatr. 1981;24(8):786-790.   Published online August 15, 1981
A childhood case of moyamoya disease with subarachnoid hemorrhage is reported. This patient exhibited left hemiparesis, dysarthria, convulsion and mental retardation. He also had characteristic angiographic picture: occlusion of supraclinoid segment of both internal carotid arteries, combined with collateral networks in the base of brain.
A Case of Congenital Hepatic Fibrosis.
Son Moon Shin, Sang Il Lee, Joong Gon Kim, Hyo Seop Ahn, Hyung Ro Moon, Kwang Wook Ko, Je Geun Chi
Clin Exp Pediatr. 1981;24(6):577-583.   Published online June 15, 1981
Congenital hepatic fibrosis is a relatively rare liver disease in children and young adults,that is characterized by stony hard hepatomegaly and portal hypertension with relative preservation of liver function and underlying architecture. Since this Condition was first delineated by Kerr et al in 1961, approximately over 150 cases have been reported in the literature. However, congenital hepatic fibrosis was not...
Late Hemorrhagic Disease of Infancy.
Joong Gon Kim, Young Min Ahn, Hyo Seop Ahn, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1980;23(7):572-577.   Published online July 15, 1980
A hemorrhagic disease due to prothrombin complex deficiency os described in 4 infants from 1 to 11 months of age. This disease is different from the hemorrhagic disease of the newborn. The main differences are that it is found in an older age group and that intracranial hemorrhages are frequent. Rapid clinical and laboratory response after vitamin K therapy are...
Original Article
Correlation between Electrocardiographic Findings and Hemodynamics in Children with Patent Ductus Arteriousus.
Joong Gon Kim
Clin Exp Pediatr. 1979;22(6):443-450.   Published online June 15, 1979
Correlation between electrocardiographic findings and hemodynamics in 108 children with patent ductus arteriosus, confirmed by cardic catheterization at SNUH, was evaluated. The results were as follows: 1. Age at diagnosis: patients(75/108) were before 10 years old, but about one third of patients(33/108) were over 10 years old. 2. Sex distribution: M:F=1:2 3. Correlation between ventricular hypertrophy pattern by ECG and...
Statistical Analysis for the Mortality of In-Patient in Pediatric Ward.
Joong Gon Kim, Chong Koo Yun, Kwang Wook Ko
Clin Exp Pediatr. 1977;20(12):933-942.   Published online December 31, 1977
Statistical analysis for mortality of in-patient in pediatric ward in Seoul National University Hospital was carried out during the 3 years from Jan. 1974 to Dec. 1976. Total number of admitted patients was 2,234, of whom 172 expired. The following results were observed. 1. Total number of admission during the 3 years was 2,234, and male to female ratio was...
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